Genetics 495G: Genes, Development and Evolution

Course Syllabus for Spring 2000: January 4, 2000

The Pre-Modern Synthesis

M 1/10 Introductory Lecture: the modern synthesis of evolution and development
W 1/12 History of Development and Evolution
F 1/14 The Shape of the Tree of Life

Fundamentals of Developmental Genetics

W 1/19 The Cambrian explosion and the origins of multicellular life
F 1/21 Basic features of invertebrate development
M 1/24 Basic features of vertebrate development
W 1/26 Winter Storm - no class
F 1/28 Basic features of plant development
M 1/31 The conservation of regulatory mechanisms in plants and animals

Fundamentals of Evolutionary Genetics

W 2/2 Genetic distances and the molecular clock
F 2/4 Cladistics, phenetics, and phylogenetic inference
M 2/7 The concept of homology
W 2/9 Heterochrony
F 2/11 Canalization
M 2/14 Discussion / Review
F 2/16 Sex determination and Polyphenism
F 2/18 Evolutionary genomics

Fundamentals of Population Genetics

M 2/21 The major evolutionary forces: drift, migration and mutation
W 2/23 Natural selection and adaptation
F 2/25 Neutral evolution and tests of neutrality
M 2/28 Heritability
W 3/01 Quantitative Trait Loci
F 3/03 The molecular basis of phenotypic variation

Emerging Topics

M 3/06 Genetics of speciation
W 3/08 The immune system
F 3/10 Genetics and evolution of behavior

Spring Break!

Model Systems for the study of Evolution and Development

M 3/20 Eye development
W 3/22 Mid-Term Exam
F 3/24 Student Paper Preparation

M 3/27 Hox genes in invertebrates
W 3/29 Hox genes in vertebrates
F 3/31 Student Papers I

M 4/3 Segmentation in Drosophila
W 4/5 Segmentation in other arthropods
F 4/7 Student Papers II

M 4/10 Mammalian skeletogenesis
W 4/12 Student Papers III
F 4/14 Flower development

M 4/17 Student Papers IV

Easter Break

M 4/24 Vulval development in nematodes
W 4/26 Student Papers V
F 4/28 The domestication of wheat and corn

M 5/1 Student Papers VI
W 5/3 Evolution of the nervous system
F 5/5 Student Papers VII

M 5/8 Final Exam