RESEARCH (77%)
Transition state theory,
synthesis of novel inhibitors and spectrophotometric diagnostic substrates,
and molecular biology are being utilized to delineate esterase and epoxide
hydrolase mechanistic action in insects. The isolation and study of key
elements from the insect juvenile hormone regulatory system and the tick
endocrine system; and genomics, structure/activity and physiological studies
on insect digestion are being applied to research and development of novel
biological and chemical pesticides. Insect genes responsible for pesticide
metabolism (esterases, epoxide hydrolases, paraoxinases, and monooxygenases
are being applied to the bioremediation of environmental pollutants using
bacterial, viral and plant recombinants. Molecular biology studies are
being conducted in the regulation of xenobiotic metabolism in insects
and the development of biochemical and generic assays for monitoring insecticide
resistance in IPM. New technologies are being developed in the enzyme-linked
immunoassay of small molecules and enzyme-linked DNA/DNA hybridization
assays. Novel insect repellents and pesticide delivery technology are
under research and development and are at various states of commercialization
with industrial partners.
Research and Demonstration
- Juvenile Hormone
Regulation
- Tick Endocrinology
- Mechanisms and
Management of Insecticide Resistance
- Novel Insecticide
Discovery
- Insect Toxicology
- Bioremediation
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