Professor of Entomology
Genetic Pest Management
1542B Thomas Hall
Department of Entomology
NCSU Campus Box 7613
Raleigh, NC USA 27695-7613
PhD, Baylor College of Medicine, Houston
Postdoctoral, University of North Carolina at Chapel Hill and Heraklion, Greece
Our main interest is in developing transgenic “male-only” strains of insect pests for genetic control programs. For example, we have developed strains of flies that are pests of livestock (e.g. New World screwworm), which carry genetic systems that cause female lethality unless tetracycline is added to the diet. We are also interested in developing genetic systems for replacing mosquito populations with strains that have a reduced capacity to transmit diseases such as dengue fever. Our applied work is underpinned by fundamental research on the regulation of gene expression in the model insect Drosophila melanogaster. For example, we have investigated how the MSL chromatin-modifying complex regulates X-linked gene expression and the importance of histone modifying enzymes in long-term memory.
ENT 506/591/791, GN 895, GES 506: "Genetic Pest Management"
GN810: Genetics colloquium on "Epigenetics"
Li, F., Vensko II, S.P., Belikoff, E.J. and Scott, M.J. (2013) Conservation and sex-specific splicing of the transformer gene in the calliphorids Cochliomyia hominivorax, Cochliomyia macellaria and Lucilia sericata. PLOS ONE, 8(2):e56303.
Concha, C., Belikoff, E.J., Carey, B., Li, F., Schiemann, A.H., and Scott, M.J. (2011) Efficient germ-line transformation of the economically important pest species Lucilia cuprina and Lucilia sericata (Diptera, Calliphoridae). Insect Biochemistry and Molecular Biology, 41: 70-75.
Fitzsimons, H.L. and Scott, M.J. (2011) Genetic modulation of Rpd3 expression impairs long-term courtship memory in Drosophila. PLoS ONE, 6(12): e29171.
Li, F., Schiemann, A.H. and Scott, M.J. (2008) Incorporation of the non-coding roX RNAs alters the chromatin binding specificity of the Drosophila MSL1/MSL2 complex. Mol. Cell. Biol. 28: 1252-1264.
Heinrich, J.C. and Scott, M.J. (2000) A repressible female-specific lethal genetic system for making transgenic insect strains suitable for a sterile-release program. Proc. Natl. Acad. Sci. USA, 97: 8229-8232.