Carrie A. Smith
Research Interests
I am a PhD student in the Department of Genetics. My research interests involve studying gene regulation of the aflatoxin biosynthesis pathway. I am currently working on three projects:
1) Natural antisense transcripts(NATs) in Aspergillus flavus with a focus on a NAT specific to the aflatoxin transcriptional regulator AflR
2) Characterization of a dominant aflatoxin mutation and the silencing effect it has on the aflatoxin gene cluster in a diploid strain of Aspergillus flavus
3) The role of the NADH oxidase gene nadA in aflatoxin biosynthesis and oxidative stress in Aspergillus flavus
Publications
Smith, C.A., Woloshuk, C.P., Robertson, D., and Payne, G.A. (accepted for publication). Silencing of the aflatoxin gene cluster in a diploid strain of Aspergillus flavus is suppressed by ectopic aflR expression. Genetics.
Price MS, Yu J, Nierman WC, Kim HS, Pritchard B, Jacobus CA, Bhatnagar D, Cleveland TE, Payne GA. The aflatoxin pathway regulator AflR induces gene transcription inside and outside of the aflatoxin biosynthetic cluster. FEMS Microbiol Lett. 2006 Feb;255(2):275-9.
Posters and Abstracts
Posters
24th Fungal Genetics Conference (Pacific Grove, CA-March 2007): The NADH oxidase nadA and its involvement in oxidative stress in Aspergillus flavus.
8th European Conference on Fungal Genetics & 3rd International Aspergillus Meeting (Vienna, Austria-April, 2006): Silencing of the Aflatoxin Cluster in a Diploid Strain of Aspergillus flavus
18th Annual Multi-Crop Aflatoxin Elimation Workshop (Raleigh, NC-October, 2005): nadA, a Gene Regulated by AflR, does not appear to Affect Aflatoxin Production.
23rd Fungal Genetics Conference (Pacific Grove, CA-March, 2005): Understanding the Link between a Natural Antisense Transcript and the Regulation of Aflatoxin Biosynthesis.
Keystone Symposia: Emerging Mechanisms of Epigenetic Regulation (Tahoe City, CA-January, 2004): Episomal down-regulation of gene expression in plants and fungi.
Abstracts
APS (San Diego, CA-July 2007): NADH oxidase nadA, a link between aflatoxin and oxidative stress in Aspergillus flavus.
31st Annual Genetics Graduate Student Symposium (Raleigh, NC-March 2007): NADH oxidase nadA and its involvement in oxidative stress in Aspergillus flavus.
APS (Quebec City, Canada-July, 2006): Silencing of the aflatoxin cluster in a diploid strain of Aspergillus flavus is relieved by ectopic aflR expression.
8th European Conference on Fungal Genetics & 3rd International Aspergillus Meeting (Vienna, Austria-April, 2006): Silencing of the Aflatoxin Cluster in a Diploid Strain of Aspergillus flavus.
30th Annual Genetics Graduate Student Symposium (Raleigh, NC-February, 2006): Trans-sensing Mechanism in a Diploid Strain of Aspergillus flavus.
18th Annual Multi-Crop Aflatoxin Elimation Workshop (Raleigh, NC-October, 2005): nadA, a Gene Regulated by AflR, does not appear to Affect Aflatoxin Production.
19th Annual Plant Molecular Biology Retreat (Wrightsville Beach, NC-September, 2005): Trans-sensing Mechanism in a Diploid Strain of Aspergillus flavus.
29th Annual Genetics Grauate Student Symposium (Raleigh, NC-April, 2005): Understanding the Link between a Natural Antisense Transcript and the Regulation of Aflatoxin Biosynthesis.
23rd Fungal Genetics Conference (Pacific Grove, CA-March, 2005): Understanding the Link between a Natural Antisense Transcript and the Regulation of Aflatoxin Biosynthesis.
28th Annual Genetics Graduate Student Symposium (Raleigh, NC-March, 2004): Geminivirus Induced Transgene Silencing in Arabidopsis: Targeting Transcribed and Untranscribed Sequences.
Keystone Symposium: Emerging Mechanisms of Epigenetic Regulation (Tahoe City, CA-January, 2004): Episomal down-regulation of gene expression in plants and fungi.
17th Annual Plant Molecular Biology Retreat (Wrightsville Beach, NC-September, 2003): Movement of the Silencing Signal.
27th Annual Genetics Graduate Student Symposium (Raleigh, NC-March, 2003): Localization of Geminivirus RF DNA in tobacco cell lines using GFP.
Curriculum Vitae
CV
Contact Information
cajacobu@unity.ncsu.edu
Lab phone: 919-515-6995
Links
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