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Dr Gary Payne
Research Interests
Genomic approaches and field studies are being used in my program
to improve food safety and to understand fungal biology and secondary
metabolism. Gene expression profiling is being used to characterize
the regulatory circuits in Aspergillus flavus governing aflatoxin
biosynthesis. Field and laboratory studies are focused on understanding
the ecology of Aspergillus flavus and Fusarium
verticillioides and the inheritance of resistance to the fungi. Maize seed proteins
inhibitory to mycotoxin-producing fungi are being isolated and
characterized to better understand resistance mechanisms in seeds.
Publications
Scholarly Accomplishments-List of Publications (last
five years)
Original Research Articles in Refereed Journals:
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Nielsen, K, G. A. Payne and R. S. Boston. 2001. Maize
ribosome inactivating protein inhibits normal development of Aspergillus nidulans and Aspergillus flavus. Mol.
Plant Microb. Int. 14:164-172.
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Price, M. S., J. J. Classen, and G. A. Payne. 2001. Aspergillus niger absorbs
copper and zinc from
swine wastewater. J. Bioresour. Technol. 77:41-49.
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OBrian, G. O., Fakhoury, A. M. and Payne, G.A. 2003. Identification
of genes differentially expressed during aflatoxin biosynthesis
in Aspergillus flavus and Aspergillus parasiticus.
Fungal
Genetics and Biology. 2003. 39:118-27.
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Brown, R. L., C. S. Brown-Jenco, Bhatnagar, D., and Payne,
G.A. 2003. Construction and preliminary evaluation of
an Aspergillus flavus reporter gene construct
as a potential tool for screening aflatoxin resistance. Journal
of Food Protection. 66:1927-1931.
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Moore, K. G., Price, M. S., Boston, R. S., Weissinger, A.K.,
and Payne, G. A. 2004. A Chitinase from Tex6 Maize
Kernels Inhibits Growth of Aspergillus flavus. Phytopathology
94:82-87.
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Bush, B. J., Carson, M. L., Cubeta, M. A., Hagler, W. M.,
and Payne, G. A. 2004. Infection
and Fumonisin Production by Fusarium verticillioides in developing
maize kernels. Phytopathology
94:88-93.
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Pirttilä, A. M., McIntyre, L. M., Payne, G. A., and Woloshuk,
C. P. 2004. Expression profile analysis of wild-type
and fcc1 mutant strains of Fusarium verticillioides during
fumonisin biosynthesis. Fungal
Genetics and Biology 41:647–656.
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Yu, J. J., Chang, P.K. Ehrlich, K.C., Cary.
J. W., Bhatnagar, D. Cleveland, T. E. Payne, G. A., Linz,
J. E., Woloshuk, C. P. and Bennett, J. W. 2004. Clustered
pathway genes in aflatoxin biosynthesis.
Applied
and Environmental Microbiology 70: 1253-1262.
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Xue, H. Q., T. G. Isleib, G. A. Payne, W. F. Novitzky, and
G. OBrian. 2005. Aflatoxin Production
in Peanut Lines Selected To Represent a Range of Linoleic Acid
Concentrations. Journal
of Food Protection 68:126-132.
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Price, M. S., Conners, S. B., Tachdjian, S., Kelly, R. M.
and Payne, G. A. 2005. Aflatoxin conducive
and non-conducive growth conditions reveal new gene associations
with aflatoxin production.
Fungal
Genetics and Biology 42:506-518.
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Robertson, L.A., Kleinschmidt, C.E., White, D.G., Payne, G.A.,
Maragos, C.M., and Holland, J.B. 2005. Heritabilities
and correlations of Fusarium ear rot resistance and fumonisin
contamination resistance in two maize populations. Crop
Science 46:353-361.
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Price, M. S., J. Yu, W. C. Nierman, H. S. Kim, B. Pritchard,
C. A. Jacobus, D. Bhatnagar, T. E. Cleveland,
and G. A. Payne. 2006. The aflatoxin pathway
regulator AflR induces gene transcription
inside and outside of the aflatoxin biosynthetic cluster.
FEMS
Microbiology Letters 255:275-9.
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Robertson, L. A., Jines, M.P., Balint-Kurti, P. J., Kleinschmidt,
C. E., White, D. G., Payne, G. A.,
Maragos, C. M., Molnár, T. L. and Holland. J. B. 2006.
QTL mapping for Fusarium ear
rot and fumonisin contamination resistance in two populations
of maize (Zea mays). Crop
Science (accepted)
Research review articles in peer-reviewed journals:
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Scheidegger, K. A. and Payne, G. A. 2003.
Unlocking the secrets behind secondary metabolism: a review of Aspergillus flavus from
pathogenicity to functional genomics. J. of Toxicology 22:423-459.
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Payne, G. A., A.M. Fakhoury, K. A. Scheidegger, M.S. Price.
2004. Genomic analysis of aflatoxin
biosynthesis. Pages 89-97, in New Horizon of Mycotoxicology
for Assuring Food
Safety. Proceedings of the International Symposium
of Mycotoxicology in Kagawa
2003, T. Yoshizawa, Ed. Tokyo, Japan.
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Georgianna, R and Payne, G. A. 2006. Regulation
of aflatoxin biosythesis. Fungal Genetics and Biology (in preparation)
Books and Book Chapters:
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Fakhoury, A. K. and Payne, G. A. 2003. Genomics of filamentous fungi: A general overview. In D. K. Arora, ed. Handbook of Fungal Biotechnology. 2nd Ed. Volume 20 of the Mycology Series.
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Price, M. S. and Payne, G. A. 2004. Genomics and gene regulation of the aflatoxin biosynthetic pathway. p.387-404. In Z. An (ed.), Handbook of Industrial Mycology. Marcel Dekker, Inc., New York.
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Bhatnagar, D., G. A. Payne, T. E. Cleveland, and J. F. Robens. 2004. Mycotoxins: Current Issues in USA. Pages 17-47, in Meeting the Mycotoxin Menace, Eds. H. Barug, H. P. van Egmond, R. Lopez-Garcia, W. A. van Osenbruggen, and A. Visconti. Wageningen Academic Publishers, Netherlands.
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Robertson, L.A., Payne, G.A., and Holland, J.B. 2005. Marker
Assisted Breeding for Host Resistance to Mycotoxin Contamination. Aflatoxin and Food Safety, edited by H. Abbas. CRC Press (In Press).
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Richard, J. L. and G. A. Payne. 2003. Eds., Mycotoxins: Risks in Plant, Animal, and Human Systems. Task Force Report 139. Council for Agricultural Science and Technology. Ames, Iowa. 199 pages.
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Payne, G. A. and Cubeta, M. A. 2005. Biology
and detection of fungal pathogens of humans and plants.
In Microbial Forensics, Eds. R.G. Breeze, B. Budowle, and S.
E. Schutzer. Elsevier
Academic Press. New York.
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Payne, G. A. Genomics of Aspergillus flavus. In, The Aspergilli: Genomics, Medical Applications, Biotechnology, and Research Methods. Osmoni and Goldman CRC Press 2007.
Curriculum Vitae
CV
Contact Information
Gary A. Payne,
William Neal Reynolds Professor
Graduate Admissions Coordinator
Department of Plant Pathology, Box 7567
223 Partners III
North Carolina State University
Raleigh, NC 27695-7567
Phone: 919.515.6994 Fax: 919.513.0024
Email: gary_payne@ncsu.edu
Mailing Address:
North Carolina State University
851 Main Campus Drive, Suite 233
Campus Box 7244
Raleigh, NC, 27695-7244
Links
Centre for Integrated Fungal
Research at North Carolina State
University (CIFR)
www.Aspergillusflavus.org
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