Matthew D. Koci
B. S. (1997) Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA
M.S. (1999) Infectious Diseases, University of Georgia, Athens, GA
Ph.D. (2003) Pathology, University of Georgia, Athens, GA
PO 411 Agrosecurity
PO (IMM) 757 Comparative Immunology
Nutrition, Functional Genomics, Biotechnology
My laboratory works to understand the immune mechanisms which allow an animal to recognize, respond, eliminate, and develop resistance to pathogens. Our approach involves understanding both cellular and molecular aspects of the host response. Currently there are three primary research projects in the laboratory. 1) Understanding the key innate immune responses involved in pathogenesis and disease resolution of astrovirus induced gastroenteritis, a major cause of diarrhea in turkey poults, and humans. 2) Understanding how genetic polymorphisms in innate immune response genes affect resistance and susceptibility to infection. 3) Understanding how changes in the intestinal microflora affects gut physiology, mucosal immunity, and ultimately the overall health of the animal.
R. Qiu, J. Croom, R. A Ali, A. L. Ballou, C. Smith, C. M. Ashwell, H. M. Hassan, C.-C. Chiang, and M. D. Koci. Direct fed microbial supplementation repartitions host energy to the immune system. Journal of Animal Science. .90:1-13, 2012.
R. R. Meyerhoff, P. K. Nighot, R. A. Ali, A. T. Blikslager, and M. D. Koci. Characterization of turkey inducible nitric oxide synthase and identification of its expression in the intestinal epithelium following astrovirus infection. Comparative Immunology, Microbiology, and Infectious Diseases. 35:63-9, 2012.
R. R. Meyerhoff, R. A. Ali, K. Liu, G. Q. Huang, M. D. Koci. Comprehensive analysis of commercially available mouse antichicken monoclonal antibodies for cross-reactivity with peripheral blood leukocytes from commercial turkeys. Poultry Science. 91:383-92, 2012.
P. K. Nighot, A. Moeser, R. A. Ali, A. T. Blikslager, and M. D. Koci. Astrovirus infection induces sodium malabsorption and redistributes sodium hydrogen exchanged expression. Virology. 401:146-54, 2010.
J. L. Grimes, M. D. Koci, C. R. Stark, D. P. Smith, P. K. Nighot, and T. Middleton. Biological Effect of Naturally Occurring Mycotoxins Fed to Poults Reared to 21 Days of Age. International Journal of Poultry Science. 9: 871-874, 2010.
HONORS AND AWARDS (INCL PATENTS)
Serologic assay for the detection of antibodies to type-2 turkey astrovirus. S. Schultz-Cherry and M. D. Koci. U. S. Patent 7381524 B2.
Avian Astrovirus. S. Schultz-Cherry, L. A. Kelley, M. D. Koci, B. S. Seal. U. S. Patent 6696562.