Jason C.H. Shih

Professor

jason_shih@ncsu.edu
 

Educational Background:

  • B.S. (1963) Botany, National Taiwan University, Taipei, Taiwan
  • M.S. (1966) Biochemistry, National Taiwan University, Taipei, Taiwan
  • Ph.D. (1973) Biochemistry/Nutrition, Cornell University, Ithaca, New York
  • Postdoctorate (1975) Biochemistry, University of Illinois, Urbana, IL

 

  • Faculty Membership:
  • Full Professor: Poultry Science, Biotechnology, Microbiology and Nutrition
  • Visiting Professorship and Fellowship: 
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    Six month Visiting Professor at University of Wales at Cardiff, Wales (1983)

  • One year Visiting Professor at Bowman Gray College of Medicine, Wake Forest University (1991)

  • One year Visiting Fellow at Academia Sinica, Taiwan (1997)

  • Adjunct and Visiting Professor, China Aricultural University (2002-2006)

  • Distinguished Visiting Fellow, Academia Sinica, Taiwan ( 2005-2008)

  

Research Interests:

Bio-fuel production and waste management: A bioprocess called thermophilic anaerobic digestion was developed from the laboratory to the commercial farm. The process can convert animal wastes into biogas fuel and other nutrient resources. The patented process and apparatus are simple, low-cost yet efficient in operation.

Keratinase technology: A feather-degrading bacterium was discovered and isolated. Its keratinase and the gene encoding the enzyme were isolated and sequenced. Genetic engineering improved the yield and scale-up fermentation produced the enzyme in large quantity. Application research has demonstrated that the keratinase can improve feed digestibility and degrade prion protein.

 

Inventions


1.     Shih, J.C.H. and Williams, C.M. (1990) Feather-Lysate, A Hydrolyzed Feather Feed Ingredient and Animal Feeds Containing the Same. U.S. Patent 4,908,220.

2.     Shih, J.C.H. and Williams, C.M. (1990) Method of Degrading Keratinaceous Material and Bacteria Useful Therefor. U.S. Patent 4,959,311.

3.     Shih, J.C.H. and Williams, C.M. (1991) Method of Degrading Kratinaceous Material and Bacteria Useful Therefor, A Divisional Patent. U.S. Patent 5,063,161.

4.     Shih, J.C.H. and Williams, C.M. (1992) Purified Bacillus licheniformis PWD-1 Enzyme. U.S.Patent 5,171,682.

5.     Shih, J.C.H. and Lee, G.G. (1993) Method and Composition for Maintaining Animals on a Keratin-Containing Diet. U.S. Patent 5,186,971.

6.     Shih, J.C.H., Lin, X. and Miller, E.S. (1996) DNA Encoding Bacillus licheniformis PWD-1 Keratinase. U.S. Patent 5,712,147.

7.       Shih, J.C.H., Lin, X. and Miller, E.S. (1996) DNA Encoding Bacillus licheniformis PWD-1 Keratinase. U.S. Patent 5,712,147.

8.       Shih, J.C.H. (2003) Composition and Method for Destruction of Infectious Prion Proteins. U.S. Patent 6,613,505.

9.       Shih, J.C.H. and N. Odetellah (2007) Material and Methods for Improving Growth of Meat-Type Poultry. (pending)

10.     Shih, J.C.H. and J.J. Wang (2007) Construction of Bacillus licheniformis T1 Strain and Fermentation Production of Crude Enzyme Extract Therefrom. (pending)

11.     Shih, J.C.H., Wang, J.J. and Greenhut, W.B. (2007) Asporogenic Bacillus Strain for the Production of Keratinase (pending)

  

Recent Publications:

  • Shih, J.C.H. and Wang, J.J. (2006) Keratinase technology: from feather degradation and feed additive, to prion destruction. CAB Reviews: Perspect. Agri., Vet. Sci. Nutri. Natur. Resourc. 1, No. 42, 1-6. Available online: http://www.cababstractsplus.org/cabreviews 

    Wang, J.J., Borwornpinyo, R., and Shih, J.C.H. (2007) Sup35NM-His6 aggregates: a prion-like protein useful in prion degradation studies. Enz. Microb. Tech. (in press). Available online: http://www.sciencedirect.com/

  • Wang, J.J, Garlich, J.D. and Shih, J.C.H. (2006) Versazyme, a keratinase feed additive, improves body weight, feed conversion and breast yield of broiler chickens. J. Appl. Poult. Res. 15:544-550.

  • Chen, C.Y., Rojanatavorn, K., Clark, C. and Shih, J.C.H. (2005) Characterization and enzymatic degradation of Sup35NM, a prion-like protein from yeast. Protein Sci. 14:2228-2235.

  • Odetallah, N., Wang, J.J., Garlich, J.D. and Shih, J.C.H. (2005) Versazyme supplementation of broiler diets improves market growth performance. Poultry Sci. 84:858-864.

  • Langeveld, J.P.M., Wang, J.J, Van de Wiel, D.F.M, Shih, G.C., Bossers, A., Garssen, J., Bossers, A. and Shih, J.C.H. (2003) Enzymatic degradation of prion protein in brain stem from cattle and sheep. J. Inf. Dis. 188:1782-1789

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