Matthew D. Koci

Assistant Professor

mdkoci@ncsu.edu
 

Faculty Memberships:


Educational Background:

  • B. S. (1997) Biology, Virginia Tech
  • M.S. (1999) Infectious Diseases, University of Georgia
  • Ph.D. (2003) Pathology, University of Georgia

Research Interests:

My research goals are to understand the immune mechanisms, which allow an animal to recognize, respond, eliminate, and develop resistance to viral pathogens. Our approach involves understanding both cellular and molecular aspects of the host response as well as the basic molecular virology. Currently research in the laboratory is focused on understanding the key innate immune responses involved in pathogenesis and disease resolution of astrovirus induced gastroenteritis. Astroviruses are a major cause of diarrhea in turkey poults, and humans. Our research has demonstrated that activated macrophages and, their effector molecules, may play an essential role in inhibiting viral replication.


Representative Publications:

  • Matthew D. Koci, L. A. Kelley, D. L. Larsen, and S. Schultz-Cherry. Astrovirus-induced synthesis of nitric oxide contributes to virus control during infection. Journal of Virology. 78:1564-1574, 2004.
  • Matthew D. Koci, L. A. Moser, L. A. Kelley, D. L. Larsen, C. C. Brown, and S. Schultz-Cherry. Astrovirus induces diarrhea in the absence of inflammation and cell death. Journal of Virology. 77:11798-11808, 2003.
  • Matthew D. Koci, B. S. Seal, and S. Schultz-Cherry. Molecular characterization of an avian astrovirus. Journal of Virology. 74:6173-6177, 2000.
  • Matthew D. Koci, B. S Seal, and S. Schultz-Cherry. Development of an RT-PCR diagnostic test for an avian astrovirus. Journal of Virological Methods. 90:79-83, 2000.
  • Matthew D. Koci, and S. Schultz-Cherry. Avian astroviruses. Avian Pathology. 31:213-227, 2002.
  • Stacey Schultz-Cherry, M. Koci, E. Thompson, and T. M. Tumpey. Examining the cellular pathways involved in influenza virus induced apoptosis. Avian Disease. 47:968-71, 2003.
  • Erica Behling-Kelly, S. Schultz-Cherry, M. D. Koci, L. A. Kelley, D. L. Larsen, and C. Brown. Localization of astrovirus in experimentally infected turkeys, as determined by in situ hybridization. Veterinary Pathology. 39:595-598, 2002.
  • Stacey Schultz-Cherry, D. J. King, and M. D. Koci. Inactivation of an astrovirus associated with poult enteritis mortality syndrome. Avian Disease. 45:76-82, 2001.
  • Stacey Schultz-Cherry, D. R. Kapczynski, V. M. Simmons, M. D. Koci, C. Brown, and H. J. Barnes. Identifying agent(s) associated with poult enteritis mortality syndrome: importance of the thymus. Avian Disease. 44:256-65, 2000.
back to faculty staff | top